Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices
نویسندگان
چکیده
منابع مشابه
Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptors mediating excitatory transmission throughout the central nervous system (CNS), play critical roles in governing brain function and cognition. Because NMDAR dysfunction contributes to the etiology of neurological and psychiatric disorders including stroke and schizophrenia, NMDAR modulators are potential drug candida...
متن کاملRunning head: Endogenous 24S-hydroxycholesterol modulates NMDARs
Mennerick 1, 2, 3 5 6 Author contributions: M-Y.S, Y.I., C.F.Z and S.J.M designed research and experiments; M-Y.S, 7 Y.I. and A.B. performed experiments and tissue collection for 24S-HC level measurement; M8 Y.S, Y.I., C.F.Z and S.J.M contributed to data interpretation and analysis; M-Y.S and S.J.M 9 drafted the manuscript with input from all authors. 10 11 Author affiliation: 1 Department of P...
متن کامل24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death. Unfortunately, undesired side effects have limited the strategy of inhibiting/blocking NMDARs as therapy. Targeting endogenous positive allosteric modulators of NMDAR function may offer a strategy with fewer downside...
متن کاملEndogenous waves in hippocampal slices.
Sharp waves (SPWs) are thought to play a major role in intrinsic hippocampal operations during states in which subcortical and cortical inputs to hippocampus are reduced. This study describes evidence that such activity occurs spontaneously in appropriately prepared rat hippocampal slices. Irregular waves, with an average frequency of approximately 4 Hz, were recorded from field CA3 in slices p...
متن کاملSerum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals.
The present study assessed the association between serum 24S-hydroxycholesterol (24S-OH-Chol) and 27-hydroxycholesterol (27-OH-Chol) and hippocampal volumes in 69 middle-aged cognitively normal individuals. Results showed that subjects with high levels of oxysterols had significantly larger hippocampal volumes than subjects with low levels of oxysterols. Multiple regression analysis revealed th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2016
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00890.2015